赛诺菲降胆固醇新药Praluent被判禁市12年

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(Summary description)赛诺菲的重磅炸弹　　Repatha和Praluent均为单抗药物，靶向一种名为前蛋白转化酶枯草溶菌素9(PCSK9)的蛋白，该蛋白可降低肝脏从血液中清除低密度脂蛋白胆固醇(LDL-C)的能力，而LDL-C被公认为心血管疾病(CVD)的主要风险因子。PCSK9抑制剂提供了一种全新的治疗模式来对抗LDL-C，被视为他汀类(如Lipitor和Zocor)之后降脂领域取得的最大进步。　　Present本是

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赛诺菲降胆固醇新药Praluent被判禁市12年

Categories:最新消息
Author:
Origin:
Time of issue:2017-01-09 10:42
Views:

Information

　　赛诺菲的重磅炸弹

　　Repatha和Praluent均为单抗药物，靶向一种名为前蛋白转化酶枯草溶菌素9(PCSK9)的蛋白，该蛋白可降低肝脏从血液中清除低密度脂蛋白胆固醇(LDL-C)的能力，而LDL-C被公认为心血管疾病(CVD)的主要风险因子。PCSK9抑制剂提供了一种全新的治疗模式来对抗LDL-C，被视为他汀类(如Lipitor和Zocor)之后降脂领域取得的最大进步。

　　Present本是赛诺菲寄予厚望的明星药物。分析师称，该药是个潜在重磅炸弹，到2020年，其将为赛诺菲和再生元创收20亿美元。在重磅炸弹数量日益减少的当下，对于两个公司而言，该药是个极其重要的资产。在胰岛素药物Lantus业绩表现持续走低的当前，赛诺菲寄望Praluent及另外几款新药能帮助其销售再度回暖。

　　英国医疗成本控制部门表示，Praluent年治疗费用为4000英镑，近十倍于之前的他汀类药物。目前Praluent已在美国、欧盟、加拿大、墨西哥和日本获批上市。

　　审评赛跑，专利撕咬

　　早在Praluent上市之前，安进就紧咬不放，控告其侵犯了自家药物Repatha的三项专利。其时安进的审评进程本领先赛诺菲。

　　事实证明安进的危机感是正确的。赛诺菲斥资6750万美元购得一张加速审评券，将Praluent审查周期大幅缩短，反超安进。2015年7月，安进和赛诺菲以仅差三天的时间分别在欧盟和美国获批了自家新一代PCSK9抑制剂，而后安进的Repatha也在美国上市，降脂恶战正式拉开序幕。

　　2016年3月，美国法院判定赛诺菲/再生元的Praluent侵犯了安进的Repatha两项专利权。判决前，赛诺菲和再生元承认其侵害了专利，把矛头转向了专利本身该不该被认定：“该专利超出了安进的发现，使其不正当地覆盖了新一类的疗法”。2017年1月4日，法官驳回了赛诺菲对于推翻该判决请求。

　　1月6日，美国特拉华州地区法官Sue Robinson判决赛诺菲和再生元停售Praluent12年，因该药侵犯了安进的同类药物Repatha的专利，该专利于2029年过期。当晚，安进股价盘后交易上涨4.3%，至159.51美元。再生元股价下降1.1%至376.61美元，而后停牌。

　　销售禁令于判决30日后生效，其间公司可以提出上诉。赛诺菲和再生元决意上诉，其表示“停售Praluent会极大危害患者的利益。”

　　分析师称，这个出人意料的判决可能将Repatha的销售推至高峰，当然，目前仍不排除上诉成功的可能性。而如果赛诺菲和再生元真的反转，安进将要面对的是大量保险支付方和市场的流失，同时声誉也会受损。

　　而如果上诉不成功，赛诺菲将不得不将Praluent撤出美国市场。但有分析师认为，更有可能的结果是赛诺菲将Praluent销售额的15%~20%作为专利使用费支付给安进。这样的结果会使得安进公司处于主动的地位。

　　来源：http://www.y-lp.com/pages/Article.aspx?id=5640859089507734977

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Electronic Arts pledges free use for five accessibility patents

Electronic Arts pledges free use for five accessibility patents Recently, Electronic Arts (EA) announced a patent pledge that gives other companies and developers free access to five of its current accessibility-related patents and technology. The company promised not to enforce against any party for infringing any of the listed patents. Instead, EA hopes to encourage “innovation” and build new features that make video games more inclusive on a much larger scale by opening up the patents. Electronic Arts (EA) is an American video game company founded in 1982. The company owns many popular and famous games, such as The Sims, SimCity, Apex Legends, Madden NFL and FIFA. Each of the games has more than 30 or 50 million sales volume. Significantly, esports involves FIFA and Apex Legends into the event list. Apex Legends has up to 1 billion players, and it is so popular that it has a Switch version. Within the freely available patents, one of which grabs everyone’s attention -- Apex Legends’ ping system (patent No. US 11097189). The ping system in Apex Legends, which excellently allows players to make communication and teamwork quick and easy without hearing or speaking, has been praised both as an impressive alternative to voice chat and as a great accessibility feature for players with a variety of disabilities. The other patents include the technology widely used in the FIFA and Madden NFL. The innovations can automatically detect and modify colors (patent No. US 10118097 and CN 107694092) and contrast ratios (patent No. US 10878540) to improve gamers’ visibility with colorblindness and low vision. Furthermore, one of the patents relates to personalized sound technology, helping players with hearing issues by modifying or creating music based on their preferences (patent No. US 10790919). The code of the mentioned technology is published on EA’s GitHub, and it is open to all developers. Thus, the developers can use it or adapt it for their games without spending the costs to research. It is good that EA shares the patents for free use and aims to create an accessibility-increased gaming environment for players. However, it is not “unconditional” to use the listed patents. In the pledge, EA mentioned that it may terminate the promise for a specific party which files a patent infringement lawsuit or other patent proceedings against EA. We can see parts of EV’s ambition behind the announcement—to build a large game developer league and a community of shared interests. Reference: https://www.ea.com/commitments/positive-play/accessibility-patent-pledge https://iknow.stpi.narl.org.tw/Post/Read.aspx?PostID=14562 https://www.polygon.com/22639469/apex-legends-electronic-arts-patent-pledge-accessibility-developers https://www.theverge.com/2021/8/24/22638535/ea-accessibility-patent-pledge-apex-legends-ping-system https://www.gamesradar.com/ea-secures-a-patent-for-the-apex-legends-ping-system-and-its-giving-it-away-for-free/ https://dotesports.com/apex-legends/news/apex-legends-ping-system-is-now-patent-free-for-accessibility https://www.nintendolife.com/news/2021/08/apex_legends_ping_system_now_patent-free_as_ea_announces_accessibility_pledge Recently, Electronic Arts (EA) announced a patent pledge that gives other companies and developers free access to five of its current accessibility-related patents and technology. The company promised not to enforce against any party for infringing any of the listed patents. Instead, EA hopes to encourage “innovation” and build new features that make video games more inclusive on a much larger scale by opening up the patents. Electronic Arts (EA) is an American video game company founded in 1982. The company owns many popular and famous games, such as The Sims, SimCity, Apex Legends, Madden NFL and FIFA. Each of the games has more than 30 or 50 million sales volume. Significantly, esports involves FIFA and Apex Legends into the event list. Apex Legends has up to 1 billion players, and it is so popular that it has a Switch version. Within the freely available patents, one of which grabs everyone’s attention -- Apex Legends’ ping system (patent No. US 11097189). The ping system in Apex Legends, which excellently allows players to make communication and teamwork quick and easy without hearing or speaking, has been praised both as an impressive alternative to voice chat and as a great accessibility feature for players with a variety of disabilities. The other patents include the technology widely used in the FIFA and Madden NFL. The innovations can automatically detect and modify colors (patent No. US 10118097 and CN 107694092) and contrast ratios (patent No. US 10878540) to improve gamers’ visibility with colorblindness and low vision. Furthermore, one of the patents relates to personalized sound technology, helping players with hearing issues by modifying or creating music based on their preferences (patent No. US 10790919). The

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The forum on "China's Intellectual Property-related Reform Measures and New Trends in Patent Litigation" will be held successfully!

The forum on "China's Intellectual Property-related Reform Measures and New Trends in Patent Litigation" will be held successfully! In response to the call for building a strong country with intellectual property rights, at 2 o'clock in the afternoon of October 21, the forum on "China's reform measures related to intellectual property rights and new trends in patent litigation" will be successfully held in Nanjing Jiangbei New District Industrial Technology Research and Innovation Park. The event was hosted by the Science and Technology Innovation Bureau of Nanjing Jiangbei New Area Management Committee, Nanjing Jiangbei New Area Industrial Technology Research and Innovation Park, Nanjing Intellectual Property Rights Protection Assistance Center Jiangbei New District Center, Nanjing Huaxun Intellectual Property Consultant Co., Ltd., Nanjing Intellectual Property Co-organized by the Protection Center (Nanjing Intellectual Property Rights Protection Assistance Center), Taiwan Pharmaceutical Development Association, and Gene Online. The director of Nanjing Intellectual Property Protection Center, Mou Xiaojian, delivered a speech. Director Mu expressed his warm congratulations on the holding of this event and introduced in detail the new pattern of intellectual property protection in Nanjing. He said: At present, Nanjing has implemented a rights protection assistance network in the municipal area. With full coverage, Nanjing Intellectual Property Protection Center is willing to closely communicate and interact with Nanjing's innovation entities, and provide relevant public welfare services such as rapid pre-review, rapid rights protection, and comprehensive utilization for enterprises in need. In addition, Huang Funan, CEO of Gene Online, was unable to come to congratulate due to the epidemic, and recorded a congratulatory video. In the video, he said: China Innovative Pharmaceuticals has already made many outstanding achievements on the international stage, and these are inseparable from intellectual property rights. The support of the company can also show the importance of intellectual property rights to biotechnology and pharmaceutical companies. This event invites four industry experts to focus on China's reform measures related to intellectual property rights and new trends in patent litigation, discuss with companies and universities, and make arrangements in advance. Dr. Qingchen Hou, general manager of Nanjing Huaxun Intellectual Property Consulting Co., Ltd., introduced the "Guidelines for Building a Powerful Country with Intellectual Property Rights (2021-2035)" and explained his views from four aspects: background, strategic layout, overall requirements, and organizational guarantees. . Subsequently, a detailed analysis of China's patent linkage system was carried out, and compared with the same types of cases at home and abroad, questions were raised: Why should we reward the first person who successfully challenged patents? Not the first person to file a P4 application? And have a series of discussions with you. Director Jiang Haijun of the Intellectual Property Protection Legal Committee of the Nanjing Lawyers Association gave a speech on three points: the problems after the amendment of the patent law, the enforceability of the amount of compensation, and the legal conflicts related to service inventions. Regarding the patent right evaluation report, he emphasized that the patentee, interested party or accused infringer can also proactively issue a patent right evaluation report. "Patent is a work of art that combines technology and law" is a message shared by Mr. Feng Tao from Jiangsu Junbo Law Firm at this event. Mr. Feng analyzes the big data of Chinese patent litigation cases through graphs and examples. Explore. The last topic of the event was shared by Guo Huangying, Intellectual Property Manager of Nanjing Huaxun Intellectual Property Agency (General Partnership)-China's Patent Infringement Judgment Principles and New Developments. Manager Guo explained to everyone the principles of patent infringement judgment and the necessity of patent infringement search and analysis before producing and selling products. In the intellectual property industry, ECCOM has been providing high-quality and professional comprehensive intellectual property services to enterprises and universities one step at a time. It also hopes that under the leadership of the state and the government, it will contribute to the building of a strong intellectual property nation in China. Make a contribution.

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Types of patents that are easily overlooked- Design Patent

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Colopl Settles Patent Infringement Lawsuit with Nintendo by Paying $30 Million

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2021-09-09