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The first HDAC inhibitor-Vorinostatin

Release time:

2018-08-03 14:22

Vorinostat is a novel molecular targeted anti-tumor drug,The English name isVorinostat, the trade name isZolinza®The chemical name isSuberoylanilide hydroxamic acid (SAHA), for the treatment of exacerbations, persistence, and relapses or ineffective after treatment with two systemic drugsTcell lymphoma(CTCL,A type of non-Hodgkin's lymphoma). Vorinostatin specifically binds and blocks histone deacetylase(Histone deacetylases, HDAC)In turn, it prevents the gene expression of tumor cells and induces apoptosis of tumor cells.

2006Year10Month6The U.S. Food and Drug Administration (FDA) Approved Vorinostatin Capsules(Feedback)As a new drug for the treatment of skin cancer, it is also the U.FDAFirst approved for metastatic skin that cannot be cured, worsens, or recurs after treatment with other drugsTLymphoma. Although only a moderate inhibitory effect, and the hydroxamic acid group also has a certain toxicity,HDACWidely present in chromatin, usingVorinostatMay cause adverse reactions in the body. But as the firstHDACinhibitors, realized fromDMSOThe leap to drugs, for the future development of stronger and saferHDACInhibitors provide a model and still have broad market prospects.

 

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